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[5] TC-NER also exists in bacteria, and is mediated by the TRCF (Mfd) protein

Consequently, CIC is upregulated in various cancers, including acute myeloid leukemia [59], colorectal [60], breast [51,61], prostate [62], and lung cancers [62,63], and in osteosarcoma [51]

Behavioral interventions alone rarely achieve more than 5-10% sustained weight loss, while tirzepatide consistently produces 15-23% reduction in clinical trials

Currais A, Prior M, Dargusch R, Armando A, Ehren J, Schubert D, Quehenberger O, Maher P (2014) Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimers disease transgenic mice