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However, early screening and frequent reassessment in high-risk patients can help detect emerging neuropathy and prompt early interventions that may prevent progression
Once a desired pigmentation level is achieved, the same PK/PD logic supports backing off to a maintenance schedule, often weekly or even less, while watching how quickly the tan fades
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Few patients survive beyond 12 months of age (2,3,22), with those that have growth failure often dying by four months of age (23)
