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Prx6 supports mitochondrial function and guards against NAFLD, while Prx3 detoxifies mitochondrial ROS in alcoholic fatty liver disease

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The phenotypic effects of Pnldc1 knockouts are notably less severe than those of Tdrkh knockouts, with milder impairments in piRNA synthesis and germ cell development, even though both Pnldc1 and Tdrkh knockout animals have similar deficits in piRNA 3-end trimming [454, 455]