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We suggest that translational arterial stiffness research should (i) improve clinical assessment, (ii) identify specific pheno- and endotypes, (iii) decipher underlying mechanisms and new risk factors (e.g., chronic psychosocial stress, air pollution), and (iv) develop tailored prevention and therapy approaches (Fig

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2024;7(11):e2442339

However, LPCAT3 is not required for ferroptosis induction.31 Both, non-enzymatic (Fenton chemistry) and enzymatic (lipoxygenases, LOXs) mechanisms may trigger lipid peroxidation.33,34 However, the specific contribution of each mechanism is unclear and it may differ for different ferroptosis inducers.34 At which regulatory point iron contributes to ferroptosis is unclear