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NADPH-dependent disulfide reductases Although there are hundreds of different NADPH-dependent enzymes in biology, each of which has the ability to use electrons extracted from NADPH to reduce specific organic or inorganic substrates, only two small groups of these enzymes, the Trx-disulfide reductases (TrxRs) and the glutathione-disulfide (GSSG)-reductases (Gsrs), can reduce an intracellular disulfide [42]

Even with anti-inflammatory and lipid-lowering interventions, the rupture of advanced atherosclerotic plaques remains a major risk factor for acute cardiovascular events and post-treatment recurrences (80)

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2022;18:e2202161