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In leptin-deficient obese mice, CB1-expressing presynaptic neurons change from glutamatergic to predominantly GABAergic in the lateral hypothalamic area, and because CB1 is associated with G i/o protein, this remodeling results in increased orexin-A, an orexigenic peptide (Cristino et al., 2013)
2020 Oct;90(5-6):514-526
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Among HIV-negative people, chronic inflammation contributes to an increased risk for many conditions, including obesity
