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Our results were in accordance with the reported study [29] and we also found that 12 weeks of treatment with PEE250 and PEE500 twice daily showed a significant change in TC ( 7.71% and 11.11%), LDL-C ( 11.39% and 21.8%), and TG ( 9.81% and 19.22%) and HDL-C (+ 7.33% and + 22.16%) compared to baseline for PEE250 and PEE500 respectively

Therapeutic implications: modulating nodes, not just scavenging Therapy should target network nodes and compartments, not just mop up oxidants: indiscriminate antioxidant loading can blunt adaptive signalling and leave the upstream drivers untouched, whereas node-specific, compartment-aware strategies act where the chemistry originates and where signals are decoded