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Elevated UVRAG expression results in diminished autophagy and increased tumorigenicity [135, 136]

Nature 549 (7672), 399403

Several mid-stage trials will read out in 2025 to provide important proof points for novel MoAs and their potential for differentiation, e.g., Lillys bimagrumab (activin/myostatin type II receptor inhibitor) in combination with semaglutide, aiming to deliver weight loss while preserving muscle mass (phase 2b)

The latter plays a key regulation feature inhibiting the hypothalamic-pituitary-adrenal (HPA) axis through negative feedback at the pituitary gland, hypothalamus, and medial prefrontal cortex, reducing CRF secretion [rewieved in (138)]