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ROS and RNS derived from NO and superoxide may also inhibit mitochondrial brain energy metabolism (Valko et al

To counter these threats, cells have evolved molecular chaperones that mitigate the toxic effects of such proteins by preferentially binding to exposed hydrophobic regions, thereby facilitating their refolding or targeting them for degradation 62,94
Comparison of autism spectrum disorder subtypes based on functional and structural factors

Instead, numerous small molecule inhibitors exert their anti-cancer effects through off-target interactions, with their anti-tumor activity either independent of, or partially reliant on, their intended targets [6,7,8]
