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Sensory symptoms usually develop first in the feet and handsreflective of the axon length, with longer neurites affected firstand manifest as numbness, tingling, paresthesias and dysesthesias induced by touch, warm or cool temperatures, impaired vibration and altered touch sensations

Biochem J 134:707716 Brigelius-Flohe R, Maiorino M (2013) Glutathione peroxidases

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PradoAFPernomianLAzevedoACostaRRizziERamosJet alMatrix metalloproteinase-2-induced epidermal growth factor receptor transactivation impairs redox balance in vascular smooth muscle cells and facilitates vascular contraction