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Responder (R) and Non-Responder (NR) groups were defined using a zero-centered threshold on the z-scored WRS (R 10% of body weight which would require euthanasia via protocol

Aug 1 2022;10(8)doi:10.3390/biomedicines10081848 Parel PM, Berg AR, Hong CG, et al

Hussain SP, Amstad P, He P, Robles A, Lupold S, Kaneko I, Ichimiya M, Sengupta S, Mechanic L, Okamura S, Hofseth LJ, Moake M, Nagashima M, Forrester KS, Harris CC (2004) p53-Induced Up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis

Also, there are 47.5 million cases of dementia, including 7.7 million new patients each year (Trandafir, 2016)