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Description
14q13.1-21.1 deletion encompassing the HPE8 locus in an adolescent with intellectual disability and bilateral microphthalmia, but without holoprosencephaly

It inhibits p-AKT, cyclin D1, CDK4, Bid, and Bcl-xL while upregulating p53/p21/Bax to induce S-phase arrest and apoptosis (Wang QZ

Therefore, the results of the two studies are not directly comparable and not necessarily discordant

doi: 10.1002/hep.27210
