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You may start to experience gastrointestinal symptoms such as abdominal discomfort, indigestion, diarrhea, and bloating

LEfSe is known to reduce false positives and can highlight biological consistency across subclasses, while the KruskalWallis test used alone can achieve a lower false-negative rate compared to LEfSe 38

Similar findings were reported in a 2024 meta-analysis of probiotics and synbiotics in critical illness, that found decreased risk of ventilator associated pneumonia and length of mechanical ventilation without a change in hospital mortality [317]

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