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Sustained ER stress upregulates the C/EBP homologous protein (CHOP), a predominant pro-apoptotic transcription factor in ER, triggering downstream cascade responses (Kim et al., 2018)

SEL is conjugated with PEG using a reactive oxygen species (ROS)-responsive linker, forming a PEG-SEL prodrug that self-assembles into micelles as a delivery vehicle for OSI, co-delivering OSI and SEL nanoparticles effectively overcoming OSI resistance in NSCLC [111].For ALK-positive NSCLC patients, although there is a good response to ALK tyrosine kinase inhibitor (TKI) therapy, drug resistance eventually develops

Negative studies in which NAC failed to show significant improvement in postoperative pulmonary complications, frequently used very low-dose NAC (600 mg total) compared with the more common high-dose regimens [58,71,72] or examined a primary outcome of exhaled breath markers of systemic inflammation [73]

Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics