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For instance, blood samples from 72 colorectal cancer patients showed a significant reduction in epithelial markers (EpCAM, CK19, and CEA) in CTCs compared to tumor tissue, indicating that most CTCs lose their epithelial phenotype in the bloodstream

Baseline MELD-3 AUC = 0.650) suggests that disease trajectory during treatment, rather than treatment itself, is the dominant factor determining outcomes

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This phenotype is likely to be secondary either to upregulation of other Cav1.2 channels or to the existence of other mechanisms of insulin secretion unreliant on voltage gated channels as discussed next