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doi: 10.1073/pnas.1912573116
2023;253 doi: 10.1016/j.ijbiomac.2023.127184
coli L-asparaginase are still the first-line drug while Erwinia L-asparaginase is used when patients show allergic responses to native and pegylated E
Age-related microvascular degeneration, characterized by endothelial dysfunction, pathological extracellular matrix remodeling, and loss of vascular elasticity, further compromises microvascular integrity, heightening susceptibility to CMHs that eventually leads to neurological symptoms [17, 23, 27,28,29,30,31]
