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One study (76) showed that the likelihood of neurological dysfunctions is lower in a HIBD neonatal rat model undergoing hyperbaric oxygen treatment, compared with controls, suggesting that this therapy may improve prognosis via neuroprotective effects

It also modulates activity of key metalloproteinases, which are enzymes that facilitate breakdown of proteins of extracellular matrix, as well as activity of anti-proteases

Stacking at moderate doses for each compound produces complementary effects that targeting one pathway alone cannot replicate, even at supra-therapeutic doses

Commonly used in non-clinical research to track changes in tissue-response markers, barrier integrity, and signaling readouts over time (in-vitro and animal models)