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In contrast, nanoparticles with diameters ranging from 100 to 700 nm are favorable for nose-to-brain delivery, an alternative route that bypasses the BBB (Markova et al., 2022)

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These factors influence capillary permeability, thereby resulting in stromal edema, a hallmark of this phase of the cycle (Plaisier, 2011)

-Catenin binds to the Col1a1 promoter region, and this combination is related to the activity of Wnt/-catenin signalling, indicating that the canonical Wnt signalling pathway is involved in the bone phenotype of DHCR7 and INSIG1/2 defects