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The phylogenetic distribution of frataxin indicates a role in ironsulfur cluster protein assembly
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however, the combination of hypoxia and bedrest exacerbated inflammatory indicators and constipation
Ischemia-reperfusion injury (IRI) downregulates GLUT4 expression, whereas pyruvate dehydrogenase E1 subunit overexpression or dopamine receptor D4 activation upregulates GLUT4, mitigating cardiac injury 25,26
