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However, the secretion of the anti-diuretic hormone (ADH) in response to increased plasma osmolality occurs at a lower threshold than the threshold for thirst, around 280 mOsm/kg versus 290-295 mOsm/kg respectively ( Bouby and Fernandes 2003

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When shots make sense (and when they don't) Injections are the right call in specific situations: confirmed severe deficiency, pernicious anemia (where intrinsic factor is absent), or documented malabsorption that has failed to respond to oral supplementation