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Pharmacological inhibition of mTORC1 with rapamycin restores the autophagic flux and rescues the defects, pointing to pivotal and complex roles of both mTORC1 and TORC2 in the control of autophagy in the skeletal muscle from young and old individuals (Table 1)
However, this study was limited by its small sample size and potential confounding variables (e.g., population stratification)
While discernible differences in physical parameters were absent among the younger mice, evident stunted growth and reduced body weight were observed in the 6-month-old Atm -KOs (Fig
Liu W, Zeng L-L, Shen H, Zhou Z-T, Hu D
