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When stratified by administration route, the mean percentage changes were: Intramuscular (IM): 307% Oral: 285% Sublingual: 199% IM administration showed the highest average B12 increase, although oral and sublingual routes also yielded substantial improvements, supporting their use as effective and less invasive alternatives
Expert Opinion on Biological Therapy (2012) 11

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This barrier consists of tightly connected epithelial cells that regulate what can enter circulation
