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GDF8, expressed predominantly in skeletal muscle, is cleaved by all TLDs and preferentially by TLL2 due to the availability of this TLD in the muscle, while the ubiquitously expressed GDF11 is cleaved preferentially by BMP1 and TLL1 [6]

Onset of cell death (D o ) and the rate of cell death (D R ) for each cell line were determined by fitting a plateau followed by one phase association model with GraphPad Prism 8.3.1