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These measures obviously should not be considered as challengers of pharmacological treatments in very high-risk individuals in primary prevention but more as partners, as both provide complementary benefits by decreasing major cardiovascular events and mortality.

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Butyrate enhances the efficacy of chemotherapeutic agents via two mechanisms: it inhibits tumor cell glycolysis (the Warburg effect), reducing energy supply and sensitizing cells to chemotherapy, and it activates the GPR109aAKT pathway, inducing cell cycle arrest and apoptosis, thereby increasing chemosensitivity (Geng et al., 2021)