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In recent years, a new Nramp5 belonging to rice ( Os Nramp5) has been characterized, which is responsible for accumulation of Mn in rice and has been reported to encode proteins localized on plasma membrane, thus suggesting that Nramp5 is a major transporter responsible for transport of Mn and Cd (Sasaki et al., 2012)

Then, we discuss the implication of cysteine as key player in ferroptosis as a precursor for glutathione first, but also as metabolic precursor in glutathione-independent ferroptosis axis

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Limitations The lack of any measurement of nitric oxide production, which could have provided us with valuable mechanistic insights into nitric oxide metabolism, is a limitation of the present study