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161 Over a period of 24 weeks, all dosage groups of retatrutide showed significant improvements in reducing glycated hemoglobin (HbA1c) and body weight compared to the placebo group, especially in the higher dosage groups

It also impairs the function of LC by suppressing the expression of steroidogenic enzymes such as steroidogenic acute regulatory protein (StAR), cholesterol side-chain cleavage enzyme (P450scc), and 3-hydroxysteroid dehydrogenase (3-HSD), ultimately reducing testosterone synthesis (111)

Emerging evidence also highlights the pleiotropic antioxidant effects of several antidiabetic agents

Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice