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An exciting target to study TRPA1 is Mller glia, which express TRPA1 (de Arajo et al., 2020), and show oxidative stress as an early response to hyperglycemia conditions, upregulating VEGF (Rossino et al., 2020), which contributes to the injurious events in DR, such as increased endothelial permeability, angiogenesis, and apoptosis (Wang et al., 2015)

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