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ImageJ software (NIH, USA) was used for the determination of the maximal optical density

Research on mitochondrial-targeted therapies, such as those aimed at maintaining mitochondrial integrity and function, is ongoing, but the majority of these therapies are in early experimental phases with few clinical trials substantiating their effectiveness [47]

A recent analysis of the USFDA Adverse Event Reporting System revealed that patients taking both metformin and a PPI experienced significantly higher rates of hospitalizations and life-threatening complications related to B12 deficiency (such as severe neuropathy and cognitive decline) compared to those on monotherapy

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