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These results revealed that microglia-derived TNF induced COX2 and PGIS expression in spinal endothelial cells and that endothelial PGI2 played a critical role in neuropathic pain via neuronal IP receptor

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Yes, diphenhydramine (Benadryl) can be taken before injection to reduce reactions

For individuals with absorption difficulties, digestive conditions, or diagnosed deficiency, injections may be more appropriate than oral supplements