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Fertil Steril 79(2):292300 Opuwari CS, Henkel RR (2016) An update on oxidative damage to spermatozoa and oocytes
Series (S): Connecting cells positive-to-negative increases voltage
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Because the substrate-binding site does not overlap with this acidic site, it was proposed that protonation of the critical aspartate (D41) by extracellular protons causes TM1 bending, the collapse of the N-lobe cavity and concomitant extrusion of the substrate into the periplasm, and eventually the return to the inward-open state
