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Description
The downregulated expression and activity of CCO cause stiff cardiomyocyte fibers, increased glycogen and lipid droplets, and dysfunctional cardiac tissue, resulting in fatal heart disease [42, 46]
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Raised iron levels can also be genetic in origin
For metabolism of NR, NRK1 is expressed in most tissues but is absent in the spleen and white adipose tissue, while NRK2 is only present in skeletal muscle, heart, and white adipose tissue (WAT) 40
