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Intervention Strategies to Reduce TMAO Concentrations Changing Dietary Habits TMAO is mainly derived from the gut, and its concentration depends on the type and amount of dietary nutrients consumed (Figure 2)

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More severe side effects such as liver damage, kidney damage, kidney stones, and compartment syndrome have been reported, but these are usually associated with higher dosages or underlying health conditions [9]

Esterification of caffeic acid with a sugar moiety, as seen in chlorogenic acid, reduces its activity (Chen and Ho 1997)