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Description
Motor : muscle weakness, ataxia, reduced reflexes (if peripheral neuropathy) or increased reflexes and/or upgoing plantars (if central neuropathy)
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PRMT5 also methylates the c-Myc agonist Mxi1 to promote -Trcp ligase-directed degradation of Mxi1
However, the recent development of human mini-colons with long-term viability in a microfluidic platform might offer one avenue for follow-up studies on this topic 79
