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doi: 10.1081/CLT-100102421
doi: 10.1039/JR9340001192 64 HayashiN.SasakiS.TakahashiH.YamashitaY.NaitoS.OnouchiH
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Subsequent work further established that the antifolate compounds LTX and PTX inhibit SHMT2, with LTX identified as the most potent SHMT2 inhibitor reported to date, followed by PTX [161]