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Rev Cardiovasc Med
While treatment was well tolerated it did not improve plasma levels of oxidative stress markers such as F2 isoprostane, isofuran, and IL-6 (Himmelfarb et al
Thus, workers submitted to intense heat as cooks, bakers, metallurgists, glassmakers, and drivers should be advised of the role of intense heat in the chronicity of melasma

Moderate heterogeneity ( I = 41.2%) was observed, reflecting some consistency among studies
