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Current Approaches in the Management of Squamous Cell adn Adenocarcinoma of the Esophagus

(2012) further optimized the hydrogen intervention strategy by comparing the effects of hydrogen water with lactulose (a synthetic disaccharide that generates hydrogen gas through gut microbiota metabolism) in a PD model

It is caused by the increase of iron-dependent reactive oxygen species due to intracellular iron overload, which leads to the accumulation of lipid peroxides, thus inducing cell membrane oxidative damage, affecting the normal life process of cells, and finally promoting the process of ferroptosis

MSG was administered orally or intravenously in order to cause pathological alterations in an animal model
