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Description
Notch signaling, initially identified in a mutant strain of Drosophila melanogaster and highly conserved throughout evolution, consists of four transmembrane receptor isoforms (Notch14) capable of binding to five different ligands (Delta-like-1, -2, -4, Jagged1, Jagged2) and participating in a variety of biological processes like cell fate (proliferation, differentiation, survival) and tissue homeostasis [153,154]

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