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In the United States alone, the annual cost of PD exceeds $52 billion, including direct medical expenses and indirect costs such as lost productivity and caregiver burden ( This review synthesizes contemporary insights into PDs pathophysiology, genetic and environmental risk factors, comorbidities, and therapeutic innovations

Additionally, dopamine modulates hippocampal neurogenesis by promoting the proliferation of neural progenitor cells in the dentate gyrus, a process essential for learning and memory [104]

Electrophysiologic Measurements There are a variety of electrophysiologic methods that can be used to objectively assess spasticity

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