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The two active sites of TIGAR are open, positively charged and can bind to other small molecules (Li and Jogl, 2009)

The median Cmax in this study is significantly lower than that considered therapeutic for preventing organ transplant rejection in humans, where a blood concentration of 8-15 ng/ml is often desired.[14, 53] This is intentional, as our goal was to use a dose that results in measurable blood concentrations, but not with the objective of causing immunosuppression