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In the last decades, a great deal of research aimed at clarifying the role played by GSTs in drug resistance, at developing inhibitors to counteract this activity but also at exploiting GSTs for prodrugs specific activation in cancer cells

Notably, Chlorella products contain a considerable amount of arginine (approximately 3200 mg/100 g dry weight), which serves as a substrate for the production of NO, a potent intracellular signaling molecule that influences every mammalian system [20]

When SAH accumulates, it can inhibit many SAM-dependent methyltransferases even if SAM itself is not severely low

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