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A 1987 study on mice determined oral glutathione to be nontoxic,27 and a 2017 toxicity study (also on mice) found that glutathione's LD (the amount of a substance needed to kill 50% of all test animals in one dose) was 5g/kg.6 An equivalent toxic dose for an 80kg human would be 32.5g, which is more than 32 times the highest amounts used in clinical studies

J., Cho, H., & Jeon, H

The best time to take B12 for weight loss is usually in the morning to maximize daytime activity and prevent potential sleep disturbances if taken at night

NICE and BNF Guidance: You correctly point out that even official guidance from NICE and the BNF acknowledges that some individuals may require more frequent injections