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a separate Merck Phase 2b trial in hip-fracture patients (Adunsky et al., 2011, PMID 21067829) was stopped early after a cardiac safety signal emerged

*Correspondence: Jialing Hu, [email protected] Li, [email protected] Mei, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

These lesions were characterized by severe proximal and distal tubular cell swelling (cell degeneration), tubular cell necrosis, and a deterioration of the architecture of the kidney