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However, a 2014 study showed that, within the study population, acetyl-L-carnitine supplementation worked as well as some major antidepressants, with fewer side effects

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however, species-specific differences may limit translation, and studies using fully humanized BBB models are needed to improve clinical relevance (Guerrero et al., 2026)

The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease
