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EECs, located in the mucosal lining from the stomach to the rectum, secrete over 20 hormones, including GLP-1, PYY, and cholecystokinin (CCK) ( 4.2.1 GLP-1 and GLP-2 As core components of the incretin system, glucagon-like peptide-1 (GLP-1) secreted by intestinal L-cells not only regulates glucose metabolism through glucose-dependent insulin secretion enhancement and glucagon suppression but also induces weight loss via gastric emptying delay and appetite inhibition