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These studies, including work from Cornell University and other institutions researching metabolic syndrome, chose subcutaneous administration because it allows precise control over plasma pharmacokinetics

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"The NADPH-dependent thioredoxin system constitutes a functional backup for cytosolic glutathione reductase in Arabidopsis"

Reported adverse effects of IV glutathione include adverse cutaneous eruptions including potentially fatal Stevens-Johnson syndrome and toxic epidermal necrolysis, severe abdominal pain, thyroid dysfunction, renal dysfunction, and lethal complications such as air embolism or potentially fatal sepsis due to incorrect/unsterile method of IV administration, with side effects on the use of injectable glutathione for skin lightening including toxic effects on the liver, kidneys, and nervous system