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Abstract Background Muscle cramps are among the common debilitating complications of liver cirrhosis

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We know that the mutation in MELAS impairs the assembly of protein complexes in the respiratory chain, resulting in impaired mitochondrial energy production, microvascular angiopathy and NO deficiency, which together can impair cerebral vasodilation.3,5 These symptoms can be exacerbated by a compensatory inflammatory response present in critically ill patients