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48), the Traditional Chinese Medicine Science and Technology Project of Jilin Province (2023021), and the Jilin Provincial Science and Technology Development Plan (YDZJ202301ZYTS184)

American journal of physiology Endocrinology and metabolism

Figure 1 Realistically, spermatozoa undergo apoptosis due to the activation of an enzyme that cells utilize for their survival, known as phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) ( 2 -related death promoter (BAD), which, once dephosphorylated, form pro-apoptotic pores in the mitochondrial membrane and foster pore formation with BAK/BAX ( ROS and the capacitation process ROS are stimulated by several mechanisms that are based on the activation of adenylyl cyclase activity ( 2 0 2 plays the key role during capacitation of mediating the processes of phosphorylation and capacitation, and this has been well reported in suspensions of hamster, bovine, and human sperm ( 2 0 2 is illustrated by catalase, which restores the spontaneous induction of tyrosine phosphorylation in capacitating mammalian spermatozoa, and hence, reduces functions, such as hyperactivation, acrosomal exocytosis, and sperm-egg fusion