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170174 DNA methylation has frequently been seen as a significant etiologic factor in disorders of the cardiovascular system

Vitamin D may have a beneficial effect on insulin action: 4 directly, by stimulating the expression of insulin receptors, thereby enhancing insulin responsiveness for glucose transport indirectly, via its role in regulating extracellular calcium, which is essential for insulin-mediated intracellular processes in insulin-responsive tissues Vitamin D can also down regulate activation of NF-kB which is an important regulator of genes encoding the pro-inflammatory cytokines implicated in insulin resistance 5 It is also closely associated with metabolic syndrome and obesity

Sasaki M, Yuki K, Kurihara T, Miyake S, Noda K, Kobayashi S, Ishida S, Tsubota K, Ozawa Y: Biological role of lutein in the light-induced retinal degeneration

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