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The Nakayama Alzheimer's disease study demonstrated that cognitive function in older adults, including controls, patients with mild cognitive impairment, and those with AD, was linked to alterations in plasma metabolites such as reduced levels of lysine, ornithine, and uracil (Ozaki et al., 2016

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doi: 10.1172/JCI200316069 39 WangPXuLBaiMZhengXSongJXieYet al