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27 investigated five patients with clEDS and histological investigations reported gross abnormalities of the elastic fibers and microfibrils in the dermis of these patients and reduced dermal collagen content
In Japan, GHD is diagnosed when the peak GH is 6.0 ng/mL in two GH secretion tests 9

28 Half-Life and Steady State If the dose of a drug that is administered is greater than the dose that is eliminated during the dosing interval, it will take about 5 half-lives for a drug to reach steady state levels

L., Ahmad, R., Bhat, A
